Adjunctive estrogen patches significantly improve positive and negative symptoms of schizophrenia in premenopausal women, new research suggests.
The study, a randomized controlled trial, replicates previous research but also extends it.
The beneficial effect of the patch was especially evident in women older than 38 years.
"Things can be statistically different but clinically meaningless," Dolores Malaspina, MD, professor of psychiatry, neuroscience, genetics, and genomic sciences at Icahn School of Medicine at Mount Sinai, New York City, told Medscape Medical News.
The study was published online July 31 in JAMA Psychiatry.